11 The American Sleep Disorder Association considers melatonin an experimental drug and does not recommend its use without medical supervision. 10 In Europe, melatonin is available by prescription only under the brand name Circadin, which is marketed as monotherapy for the short-term treatment of primary insomnia characterised by poor quality of sleep in patients who are aged 55 or over. Oral melatonin is included in the Natural Health Products ingredients/monograph database for Health Canada. Use of animal based melatonin products is not recommended due to the potential risk of contamination from animal-based infectious prions and viruses, which may cause serious illness. Commercial melatonin products are primarily synthesized from 5-methoxyindole rarely, commercial products are derived from animal (bovine) pineal glands. Melatonin was isolated from the pineal gland in 1958. Clinical study of melatonin continues to elucidate the role of melatonin in a variety of neurologic, hormonal, gastrointestinal, and neoplastic disorders The effects of melatonin as a hormone were first noted in 1917, when dark-skinned tadpoles fed a pineal gland extract were noted to develop lighter skin. Melatonin plays a proven role in maintaining sleep-wake rhythms, and supplementation may help to regulate sleep disturbances that occur with insomnia, jet lag, rotating shift-work, depression, chronic kidney disease, critical care unit stays, and various neurological disabilities.

Endogenous melatonin is secreted by the pineal gland in all animals exhibiting circadian or circannual rhythms. Melatonin or 5-methoxy-N-acetyltryptamine is a neurohormone used to regulate sleep-wake cycles in patients with sleep disorders. 6 7 8 Magnesium chloride is expressed in breast milk in lactating mothers and is classified by the Food and Drug Administration as a pregnancy category C drug it should only be administered in pregnant mothers when the benefits of administration outweigh the risks. 5 Administered parenterally, some clinical indications for the use of magnesium chloride include peritoneal dialysis, total parenteral nutrition (TPN), fluid and electrolyte replacement, and the management of cardiovascular diseases such as congestive heart failure, supraventricular tachycardia, ventricular arrhythmia, and atherosclerosis. Highly water-soluble, it comprises a magnesium halide bound to two inorganic chloride ions. Magnesium chloride is one of the most common magnesium salts that is used clinically. 4Ĭlinically, magnesium is administered in the body as magnesium salts. 2 3 Generally, magnesium is typically found in food sources such as cereals and legumes, and is excreted renally from the body. Magnesium also is integral in the regulation of the enzyme Na+/K+ ATPase which controls the intracellular as extracellular flow of sodium and potassium in living cells. 1 Additionally, magnesium is important for glycolysis, oxidative phosphorylation, osteogenesis and bone ossification, and RNA as well as DNA synthesis. Magnesium, a divalent cation as well as the second most common intracellular cation in the body after potassium, plays a fundamental role in a significant number of enzymatic reactions pertaining to nucleic acid synthesis and energy metabolism. Relax Max Cream (Magnesium Chloride / Melatonin / Taurine / Theanine) 10/0.3/25/10% General Information Magnesium Chloride Relax Cream (Magnesium Chloride / Melatonin / Taurine / Theanine) 10/0.3/10/5% Overview of Relax Cream (Magnesium Chloride / Melatonin / Taurine / Theanine)ĭosage Strengths of Relax Cream (Magnesium Chloride / Melatonin / Taurine / Theanine)

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